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分类: 医疗健康 >> 内科
问题描述:
最好是英文的，谢谢了！
解析:
Helminthic infections have been shown to inhibit allergy skin-prick tests and to modify the course of asthma. We evaluated Dermatophagoides pteronyssinusspecific immune responses in patients with asthma by measuring levels of T helper 2 (Th2) cytokines in peripheral blood mononuclear cell (PBMC) cultures. PBMCs from Schistosoma mansoniinfected patients with asthma living in an area of polyhelminthic endemicity produced lower levels of interleukin (IL)5 and IL-4 in response to D. pteronyssinus antigen (Ag) 1 than did PBMCs from helminth-free patients with asthma. In contrast, D. pteronyssinus Ag 1specific production of IL-10 was higher in helminth-infected patients than in helminth-free patients. The addition of rebinant human IL-10 to D. pteronyssinus Ag 1stimulated cultures of PBMCs from helminth-free patients led to down-modulation of production of IL-5. After helminth-infected patients with asthma received antihelminthic treatment, there was down-modulation of D. pteronyssinus Ag 1specific production of IL-10 in vitro. S. mansoniinfected patients with asthma produce lower levels of Th2 cytokines than do helminth-free patients with asthma, and this modulation is likely done by IL-10.
Parasites, Allergy, and Asthma
John Britton, M.D.
University of Nottingham Nottingham, United Kingdom
Asthma is generally more mon in developed than developing countries, and within developing countries, it tends to be rare in rural relative to urban populations (1). This indicates either that environmental factors associated with urbanization and affluence cause asthma or that aspects of a rural subsistence lifestyle prevent it. Given the clinical significance of the asthma epidemic in developed countries in recent decades, it is of obvious importance to investigate the factors responsible.
It was first suggested that intestinal parasite infections may be involved, possibly by blockade of allergen-specific IgE binding on mast cells by the high levels of IgE produced in response to the parasite (2), in the early 1970s. Epidemiologic interest in parasite effects persisted into the 1980s but appears to have diminished after a 1985 review concluded that the data “neither refute nor support the theory that parasite infection protects against asthma” (3). Recently however, the parasite hypothesis has again begun to attract attention (4–9), and in this issue of AJRCCM (pp. 313–317) Cooper and colleagues (10) report cross-sectional evidence that parasites protect against allergic sensitisation and exercise-induced wheeze, but not other allergic symptoms, in children in Ecuador. Their findings on allergic sensitization are essentially similar to those reported in a subgroup of the same population in another article (11), which also presents data on total and specific IgE, but not symptoms. It is unfortunate that all of these data, if available for all of the participants in the present study, were not presented in a single report.
Several of the recent studies provide evidence of protection by parasites against allergic sensitization. In Gabonese children, Schistosoma infection is associated with a reduced risk of skin sensitization to house dust mite (6), an effect apparently mediated by interleukin-10 rather than IgE blockade (6, 12). Reduced allergic sensitization in the presence of helminth infection is also reported in *** s from The Gambia (4), whereas a Venezuelan study has demonstrated that parasite eradication increases allergic skin sensitization and allergen-specific IgE levels in children (13). These findings are all therefore consistent with those of Cooper and colleagues (10, 11).
In relation to wheeze or asthma, however, the data are less clear. The Gabon study did not present data on symptoms (6), but a study from Brazil suggests that asthma may be less severe in children infected with Schistosoma (7). Physician-diagnosed asthma has also been reported to be less mon in Taiwanese children infected with pinworm (data on allergic sensitization not presented) (9), again suggesting a protective effect. In the Gambian study, however, neither helminth infection nor allergic sensitization was related to wheeze (4), whereas a study from China has reported an increased risk of childhood asthma as well as allergic sensitization in association with Ascaris infection (14). In Venezuela, eradication of parasites in children with asthma appears to have caused improvement, rather than deterioration, in asthma severity (15). These data are clearly much less indicative of protection against asthma, and the study from Ecuador is equivocal in this respect: parasite infections were associated with reduced risks of symptoms of asthma, rhinitis, and eczema, but significantly so only for exercise-induced wheeze (10).
Our own findings in Ethiopia are different again from many of these studies. We have shown a strong and intensity-related reduction in the risk of wheeze with parasite infection in independent studies of *** s (5) and young children (8), but an increased risk of sensitization to Dermatophagoides pteronyssinus in rural *** s infected with parasites, with dissociation from an increased risk of wheeze in the presence of higher-intensity parasite infection (5). In young children, allergic sensitization was unrelated to parasite infections or wheeze (8).
Why do these inconsistencies arise? Aside from false positive and negative findings, one obvious possibility is that some cross-sectional associations are due to confounding by exposure to endotoxin, hepatitis A, allergens, or any of the other factors linked to the etiology of asthma. Hepatitis A infection and Der p1 exposure did not confound our results in *** s in Ethiopia (5), but much larger studies than are currently available are necessary to fully resolve these issues. A second explanation is that allergic individuals are less likely to bee infected with parasites, itself an attractive explanation for the evolutionary persistence of a mon trait with little other obvious survival advantage. A further possibility is that some of these effects are parasite species-specific and that the confusion in the literature arises in part from confounding by infection with more than one parasite. Our studies, and those from the Gabon, are consistent to the extent that they demonstrate effects arising from parasites with a systemic phase in their life cycle (5, 6), in our case particularly hookworm (5). Systemic phase parasites such as the hookworm have developed defense mechani *** s to allow them to survive the powerful immune responses mounted against them by the host (16), many of which are also likely to have antiallergic activity. Not all of the available data support this idea, however, and few studies, including this latest (10), have estimated independent effects for individual parasite species.
Those seeking a simple answer may find the inconsistencies irreconcilable and conclude that this line of investigation is going nowhere. The risk of this is, however, to miss seeing the wood for the trees because many of the effects described in these studies are strong and therefore likely to reflect important etiologic influences. The studies also contain other messages that should not be ignored. Given that allergic sensitization is a strong risk factor for asthma in most developed countries, the consistent lack of association in many of these tropical populations certainly merits further investigation. If valid, the inverse relationships reported in the studies cited also have important implications for current thinking on the role of T-lymphocyte immune polarization in the pathogenesis of allergic disease. Given that eradication of parasite infection is a universal public health goal, it is also important that any potential adverse effects of this policy are properly defined. The article by Cooper and colleagues (10) is a wele contribution because it provides further evidence that something relevant lies in these associations. The challenge is to understand and apply them to practical benefit.
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参考资料：ajrccm.atsjournals/cgi/content/full/168/3/266
